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Precautions

Do NOT use Duetact if:

• you're allergic to any ingredient in Duetact
• you have moderate to severe heart failure, liver problems or abnormal liver function tests, certain severe problems associated with diabetes (eg, diabetic ketoacidosis, diabetic coma), moderate to severe burns, or high blood acid levels (acidosis)
• you've type 1 diabetes
• you consider bosentan.

Contact a medical expert or physician right away if some of these apply to you.

Some medical ailments may connect to Duetact. Tell your doctor or pharmacist when you have any health concerns, particularly if any from the following affect you:

• if you happen to be pregnant, likely to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or any other substances
• in case you have had a severe allergic reaction (eg, severe rash, hives, the like, dizziness) to any other sulfonamide medicine for example acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glipizide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
• in case you have a good reputation for kidney, thyroid, heart, or circulation problems; anemia, stroke; certain hormonal problems (eg, adrenal or pituitary problems, syndrome of inappropriate secretion of antidiuretic hormone [SIADH]); low blood sodium levels; or 'abnormal' amounts associated with an enzyme called glucose 6-phosphate dehydrogenase (G6PD)
• if you have stomach or bowel obstruction (eg, stomach or bowel blockage, stomach paralysis), are drinking alcoholic beverages, or have had poor nutrition
• if you have very poor health, a top fever, an extreme infection, severe diarrhea, high blood acid levels, or brain or nerves problems, or have had a serious injury
• for those who have a good reputation for bladder cancer, bone fracture, low calcium intake, or weak bones (eg, osteoporosis)
• when you have swelling problems (edema) or certain eye problems (macular edema)
• if you will be having surgery.

Some medicines may talk with Duetact. Tell your medical provider in case you consider another medicines, especially any in the following:

• Bosentan because liver problems may occur, and the effectiveness of both medicines could possibly be decreased
• Beta-blockers (eg, propranolol) for the reason that likelihood of low blood glucose levels could be increased. They may also hide certain indications of low blood glucose levels and earn it more difficult to notice
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, miconazole, ketoconazole), chloramphenicol, clarithromycin, clofibrate, disopyramide, fenfluramine, fluoxetine, insulin, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), and sulfonamides (eg, sulfamethoxazole) because the likelihood of low blood sugar might be increased
• Calcium channel blockers (eg, diltiazem), corticosteroids (eg, prednisone), decongestants (eg, pseudoephedrine), diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogens, hormonal contraceptives (eg, contraceptive pills), isoniazid, niacin, phenothiazines (eg, promethazine), phenytoin, rifamycins (eg, rifampin), sympathomimetics (eg, albuterol, epinephrine), or thyroid supplements (eg, levothyroxine) given that they may decrease Duetact's effectiveness, causing high blood sugar levels
• Gemfibrozil because blood sugar could be increased or decreased
• Anticoagulants (eg, warfarin) as their effectiveness could be decreased or even the likelihood of their unwanted side effects could be increased by Duetact.

This will not be a total set of all interactions that may occur. Ask your medical provider if Duetact may interact with other medicines that you just take. Check with your doctor before starting, stop, or change the dose of the medicine.

Important safety information:

• Duetact could cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects might be worse should you take it with alcohol or certain medicines. Use Duetact with caution. Do not drive or perform other possible unsafe tasks and soon you recognize how you react to it.
• Do not drink alcohol as you are taking Duetact; it might raise the probability of low blood glucose levels. Rarely, alcohol may communicate with Duetact and create a serious reaction with symptoms for example flushing, nausea, vomiting, dizziness, or stomach pain. Discuss any queries or concerns along with your doctor.
• Carry an ID card constantly that says you might have diabetes.
• Proper diet and exercise are crucial so that you can lose weight whilst them back. Follow the diet and exercise program directed at you by your doctor.
• Check your blood sugar levels levels as directed by your doctor. If they are often higher or less than they will be so you take Duetact just as prescribed, tell your physician.
• It could possibly be harder to manage your blood glucose during times of stress including fever, infection, injury, or surgery. Talk along with your doctor about how to regulate your blood sugar if all of these occur. Do not alter the dose of one's medicine without checking together with your doctor.
• Do not take more than the recommended dose without checking along with your doctor.
• Duetact could cause low blood sugar levels levels. Low blood sugar levels will make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also build your heart rhythm faster; make your vision change; give you a headache, chills, or tremors; or allow you to more hungry. It is often a good plan to carry a dependable source of glucose (eg, tablets or gel) to take care of low blood glucose. If this is not available, you ought to eat or drink an instant method to obtain sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will increase your blood sugar levels level quickly. Tell your medical professional without delay in such a circumstance. To prevent low blood sugar levels, eat meals concurrently every day and don't skip meals.
• Risk of low blood glucose could be increased by severe or prolonged exercise, drinking alcohol, or skipping meals.
• Duetact has a sulfonylurea. It may boost the probability of death from coronary disease. Talk using your doctor in regards to the benefits and risks of this or other therapies to take care of your trouble.
• Duetact might cause ovulation ladies who have not reached menopause but don't ovulate. To avoid pregnancy, be sure to work with effective birth control method while using Duetact.
• Duetact might cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths unless you discover how you react to Duetact. Use a sunscreen or wear protective clothing should you should be outside for greater than a short period of time.
• Tell a medical expert or dentist that you take Duetact prior to deciding to receive any medical or dentistry, emergency care, or surgery.
• Duetact may be associated with an increased probability of bladder cancer. Discuss any queries or concerns together with your doctor.
• An increased incidence of bone fracture continues to be reported in ladies having Duetact. Tell your doctor when you have a reputation bone fracture, low calcium intake, or weak bones (eg, osteoporosis). Tell your medical professional right away in the event you experience any unusual bone pain.
• Lab tests, including fasting blood glucose levels, hemoglobin A_1c, liver function, and eye exams, could be performed while you use Duetact. These tests could be used to monitor your trouble or look for unwanted side effects. Be sure to keep all doctor and lab appointments.
• Use Duetact with caution within the elderly; they may be more responsive to its effects, particularly the probability of heart related illnesses or low blood sugar.
• Duetact shouldn't be found in children; safety and effectiveness in children weren't confirmed.
• Pregnancy and breast-feeding: Duetact could cause trouble for the fetus or newborn. If you think you could be pregnant, speak to your doctor. You will need to discuss the advantages and perils associated with using Duetact while you're pregnant. It is not known if Duetact is situated in breast milk. Do not breastfeed while taking Duetact.

When used for extended periods of time Duetact may not work as well. If your blood sugar may be in check then becomes difficult to manage, contact your doctor. Do not affect the dose of one's medicine without checking with your doctor.